abstract：UNLABELLED:Despite short-term efficacy, many weight loss studies demonstrate poor long-term results and have difficulty recruiting men. Cost-effective treatments that help men achieve long-term weight loss are required. Using a two-phase, assessor-blinded, parallel-group randomised controlled trial design this study wi...

journal_title：Contemporary clinical trials

authors： Young MD,Collins CE,Callister R,Plotnikoff RC,Doran CM,Morgan PJ

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:The aims of the study protocol are to investigate different adapted physical training programs in patients with advanced lung cancer undergoing palliative chemo- or radiotherapy and to evaluate their effects on physical performance, quality of life, symptom burden, and efficacy of oncologic treatment. METHODS:...

journal_title：Contemporary clinical trials

authors： Jensen W,Oechsle K,Baumann HJ,Mehnert A,Klose H,Bloch W,Bokemeyer C,Baumann FT

更新日期：2014-01-01 00:00:00

abstract：:Growing Right Onto Wellness (GROW) is a randomized controlled trial that tests the efficacy of a family-centered, community-based, behavioral intervention to prevent childhood obesity among preschool-aged children. Focusing on parent-child pairs, GROW utilizes a multi-level framework, which accounts for macro (i.e., b...

journal_title：Contemporary clinical trials

authors： Po'e EK,Heerman WJ,Mistry RS,Barkin SL

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Women have higher rates of depression and often experience depression symptoms during critical reproductive periods, including adolescence, pregnancy, postpartum, and menopause. Collaborative care intervention models for mood disorders in patients receiving care in an OB-GYN clinic setting have not been eval...

journal_title：Contemporary clinical trials

authors： LaRocco-Cockburn A,Reed SD,Melville J,Croicu C,Russo JE,Inspektor M,Edmondson E,Katon W

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Evidence suggests that periodontitis is associated with prevalent and incident type 2 diabetes mellitus (T2DM), raising the question of whether periodontitis treatment may improve glycemic control in patients with T2DM. Meta-analyses of mostly small clinical trials suggest that periodontitis treatment result...

journal_title：Contemporary clinical trials

authors： DPTT study group.,Engebretson S,Gelato M,Hyman L,Michalowicz BS,Schoenfeld E

更新日期：2013-11-01 00:00:00

abstract：:Pediatric primary care is an important setting in which to address obesity prevention, yet relatively few interventions have been evaluated and even fewer have been shown to be effective. The development and evaluation of cost-effective approaches to obesity prevention that leverage opportunities of direct access to f...

journal_title：Contemporary clinical trials

authors： Sherwood NE,Levy RL,Langer SL,Senso MM,Crain AL,Hayes MG,Anderson JD,Seburg EM,Jeffery RW

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Chronic Obstructive Pulmonary Disease (COPD) frequently coexists with other diseases. Whereas COPD action plans are currently part of usual care, they are less suitable and potentially unsafe for use in the presence of comorbidities. This study evaluates whether an innovative treatment approach directed towa...

journal_title：Contemporary clinical trials

authors： Lenferink A,Frith P,van der Valk P,Buckman J,Sladek R,Cafarella P,van der Palen J,Effing T

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Focal therapy offers the possibility of cancer control, without the side effect profile of radical therapies. Early single centre prospective development studies using high intensity focused ultrasound (HIFU) have demonstrated encouraging genitourinary functional preservation and short-term cancer control....

journal_title：Contemporary clinical trials

authors： Dickinson L,Ahmed HU,Kirkham AP,Allen C,Freeman A,Barber J,Hindley RG,Leslie T,Ogden C,Persad R,Winkler MH,Emberton M,INDEX Study Group.

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Juvenile neuronal ceroid lipofuscinosis (JNCL; Batten disease) is a rare, inherited, fatal lysosomal storage childhood disorder. True for many rare diseases, there are no treatments that impact the course of JNCL. The University of Rochester Batten Center's (URBC) mission is to find treatments to slow, hal...

journal_title：Contemporary clinical trials

authors： de Blieck EA,Augustine EF,Marshall FJ,Adams H,Cialone J,Dure L,Kwon JM,Newhouse N,Rose K,Rothberg PG,Vierhile A,Mink JW,Batten Study Group.

更新日期：2013-07-01 00:00:00

abstract：INTRODUCTION:The increasing complexities of conducting multiregional trials and an evolving regulatory environment contribute to unprecedented new challenges for use of patient-reported outcome measures (PROMs)(1) within clinical trials. This paper presents these challenges and potential solutions. METHODS:Real-world ...

journal_title：Contemporary clinical trials

authors： Gnanasakthy A,DeMuro C,Boulton C

更新日期：2013-05-01 00:00:00

abstract：:Several randomized trials have found behavior change programs delivered via text messaging to be efficacious to improve preventive health behaviors such as physical activity and stopping smoking; however few have assessed its value in skin cancer prevention or early detection. The HealthyTexts study enrolled 678 parti...

journal_title：Contemporary clinical trials

authors： Janda M,Youl P,Marshall AL,Soyer HP,Baade P

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Research demonstrates a link between migraine and obesity. Obesity increases the risk of frequent migraines and is associated with migraine prevalence among reproductive-aged women. These findings are substantiated by several plausible mechanisms and emerging evidence of migraine improvements after surgical ...

journal_title：Contemporary clinical trials

authors： Bond DS,O'Leary KC,Thomas JG,Lipton RB,Papandonatos GD,Roth J,Rathier L,Daniello R,Wing RR

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Clinical studies provide formalised experience for evidence-based medicine (EBM). Many people consider a controlled randomised trial (CRT, identical to a randomised controlled trial RCT) to be the non-plus-ultra design. However, CRTs also have limitations. The problem is not randomisation itself but informed...

journal_title：Contemporary clinical trials

authors： Gaus W,Muche R

更新日期：2013-05-01 00:00:00

abstract：:Large, "practical" or streamlined trials (LSTs) are used to study the effectiveness and/or safety of medicines in real world settings with minimal study imposed interventions. While LSTs have benefits over traditional randomized clinical trials and observational studies, there are inherent challenges to their conduct....

journal_title：Contemporary clinical trials

authors： Kolitsopoulos FM,Strom BL,Faich G,Eng SM,Kane JM,Reynolds RF

更新日期：2013-03-01 00:00:00

abstract：:Physical therapy (PT) is a key component of treatment for knee osteoarthritis (OA) and can decrease pain and improve function. Given the expected rise in prevalence of knee OA and the associated demand for treatment, there is a need for models of care that cost-effectively extend PT services for patients with this con...

journal_title：Contemporary clinical trials

authors： Allen KD,Bongiorni D,Walker TA,Bartle J,Bosworth HB,Coffman CJ,Datta SK,Edelman D,Hall KS,Hansen G,Jennings C,Lindquist JH,Oddone EZ,Senick MJ,Sizemore JC,St John J,Hoenig H

更新日期：2013-03-01 00:00:00

abstract：:Breast cancer is the most common invasive cancer among women in developed countries. Obesity is a major risk factor for breast cancer recurrence and mortality in both pre- and postmenopausal women. Co-morbid medical conditions are common among breast cancer survivors. The Exercise and Nutrition to Enhance Recovery and...

journal_title：Contemporary clinical trials

authors： Rock CL,Byers TE,Colditz GA,Demark-Wahnefried W,Ganz PA,Wolin KY,Elias A,Krontiras H,Liu J,Naughton M,Pakiz B,Parker BA,Sedjo RL,Wyatt H,Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial Group.

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Risk factors for cardiovascular disease (CVD) not only increase the risk for clinical CVD events, but also are associated with a cascade of neurophysiologic and neuroanatomic changes that increase the risk of cognitive impairment and dementia. Although epidemiological studies have shown that exercise and die...

journal_title：Contemporary clinical trials

authors： Blumenthal JA,Smith PJ,Welsh-Bohmer K,Babyak MA,Browndyke J,Lin PH,Doraiswamy PM,Burke J,Kraus W,Hinderliter A,Sherwood A

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Comparative effectiveness research (CER) evidence on childhood obesity provides the basis for effective screening and management strategies in pediatric primary care. The uses of health information technology including decision support tools in the electronic health records (EHRs), as well as remote and mobi...

journal_title：Contemporary clinical trials

authors： Taveras EM,Marshall R,Horan CM,Gillman MW,Hacker K,Kleinman KP,Koziol R,Price S,Simon SR

更新日期：2013-01-01 00:00:00

abstract：:Although progress has been made to elucidate the effects of exercise as a strategy for reducing obesity and related cardiometabolic risk factors, the specific exercise exposures required to achieve optimal benefit continue to be the source of considerable uncertainty and debate. Despite the inference of a dose-depende...

journal_title：Contemporary clinical trials

authors： Ross R,Hudson R,Day AG,Lam M

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To retrospectively analyze the effects of long-acting gonadotropin-releasing hormone agonist (GnRH-a) combined with transvaginal ultrasound-guided cyst aspiration on the pregnancy outcomes of in vitro fertilization-embryo transfer (IVF-ET) in the infertile patients with ovarian endometriosis. METHODS:The 134...

journal_title：Contemporary clinical trials

authors： Guo YH,Lu N,Zhang Y,Su YC,Wang Y,Zhang YL,Sun YP

更新日期：2012-11-01 00:00:00

abstract：:Dosing is potentially the most important decision that must be made when building or refining behavioral interventions. In this paper, we propose standardized terminology and reporting of dosing information, which would inform intervention development, refinement for dissemination, and systematic reviews of dose-respo...

journal_title：Contemporary clinical trials

authors： Voils CI,Chang Y,Crandell J,Leeman J,Sandelowski M,Maciejewski ML

更新日期：2012-11-01 00:00:00

abstract：:Research indicates that exercise is an efficacious intervention for depression among adults; however, little is known regarding its efficacy for preventing postpartum depression. The Healthy Mom study was a randomized controlled trial examining the efficacy of an exercise intervention for the prevention of postpartum ...

journal_title：Contemporary clinical trials

authors： Lewis BA,Gjerdingen DK,Avery MD,Guo H,Sirard JR,Bonikowske AR,Marcus BH

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The translation of research evidence into practice is facilitated by clinical trials such as those sponsored by the National Cancer Institute's Community Clinical Oncology Program (CCOP) that help disseminate cancer care innovations to community-based physicians and provider organizations. However, CCOP part...

journal_title：Contemporary clinical trials

authors： McAlearney AS,Song PH,Reiter KL

更新日期：2012-11-01 00:00:00

abstract：:Phase IIA clinical trials are commonly conducted as pilot studies to evaluate efficacy and safety in selected populations of patients with the disease or condition to be treated or prevented. The efficacy objective is to find preliminarily evidence of the effectiveness or ineffectiveness of study treatments. Go/no-go ...

journal_title：Contemporary clinical trials

authors： Zhong B

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Anxiety and mood disorders involve a high disease burden and are associated with high economic costs. A stepped-care approach intervention and abbreviated diagnostic method are assumed to increase effectiveness and efficiency of the mental healthcare and are expected to reduce economic costs. METHODS:Presen...

journal_title：Contemporary clinical trials

authors： Meuldijk D,Carlier IV,van Vliet IM,van den Akker-Marle ME,Zitman FG

更新日期：2012-09-01 00:00:00

abstract：INTRODUCTION:Robotic assistance during laparoscopic surgery for pelvic organ prolapse rapidly disseminated across the United States without level I data to support its benefit over traditional open and laparoscopic approaches [1]. This manuscript describes design and methodology of the Abdominal Colpopexy: Comparison o...

journal_title：Contemporary clinical trials

authors： Mueller ER,Kenton K,Tarnay C,Brubaker L,Rosenman A,Smith B,Stroupe K,Bresee C,Pantuck A,Schulam P,Anger JT

更新日期：2012-09-01 00:00:00

abstract：:Thirty percent of all military personnel smoke cigarettes. Because of the negative health consequences and their impact on physical fitness, overall health, and military readiness, the Department of Defense has identified the reduction of tobacco use as a priority of US military forces. This study aims to evaluate the...

journal_title：Contemporary clinical trials

authors： Richey PA,Klesges RC,Talcott GW,Debon M,Womack C,Thomas F,Hryshko-Mullen A

更新日期：2012-09-01 00:00:00

abstract：:Slow or insufficient enrollment in clinical research and a high demand for research participants raises questions about the need for and use of incentives to participate, including payment. Much of the available literature on payment to research participants focuses on ethical concerns, and rarely addresses guidelines...

journal_title：Contemporary clinical trials

authors： Dominguez D,Jawara M,Martino N,Sinaii N,Grady C

更新日期：2012-09-01 00:00:00

abstract：:The Rare Diseases Clinical Research Network (RDCRN) Contact Registry has grown in size and scope since it was first reported in this journal in 2007. In this paper, we reflect on our seven years' experience developing and expanding the RDCRN Contact Registry to include many more rare diseases. We present the functiona...

journal_title：Contemporary clinical trials

authors： Richesson RL,Sutphen R,Shereff D,Krischer JP

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Patients with high blood pressure (BP) visit a physician an average of 4 times or more per year in the U.S., yet BP is controlled in fewer than half. Practical, robust and sustainable models are needed to improve BP in patients with uncontrolled hypertension. OBJECTIVES:The Home Blood Pressure Telemonitorin...

journal_title：Contemporary clinical trials

authors： Margolis KL,Kerby TJ,Asche SE,Bergdall AR,Maciosek MV,O'Connor PJ,Sperl-Hillen JM

更新日期：2012-07-01 00:00:00

abstract：:An instrumental variable (IV) estimator has been widely used to estimate causal effects among compliers in randomized trials with noncompliance. The estimator of complier average treatment effect can be expressed as a ratio of two unbiased estimators but the ratio estimator is not unbiased. The bias of IV estimator ca...

journal_title：Contemporary clinical trials

authors： Chan KC

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Bipolar Disorder (BD) is a common and severe form of mental illness. Pharmacotherapy is the main treatment offered, but has limited effectiveness, and there is increasing evidence that people with BD respond well to psychological interventions. Inequalities in access to face-to-face psychological interventio...

journal_title：Contemporary clinical trials

authors： Todd NJ,Solis-Trapala I,Jones SH,Lobban FA

更新日期：2012-07-01 00:00:00

abstract：:Depression affects 20-30% of people living with HIV/AIDS (PLWHA) in the U.S. and predicts greater sexual risk behaviors, lower antiretroviral (ARV) medication adherence, and worse clinical outcomes. Yet little experimental evidence addresses the critical clinical question of whether depression treatment improves ARV a...

journal_title：Contemporary clinical trials

authors： Pence BW,Gaynes BN,Williams Q,Modi R,Adams J,Quinlivan EB,Heine A,Thielman N,Mugavero MJ

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:To explore a better administration way through comparison of the pharmacodynamics of cisatracurium administered by continuous infusion or intermittent bolus injection. METHODS:Thirty patients (ASAI-II) who had no neuromuscular disease and underwent selective surgery under general anesthesia were randomly div...

journal_title：Contemporary clinical trials

authors： Dong YJ,Li X

更新日期：2012-05-01 00:00:00

abstract：:There are few effective obesity interventions directed towards younger children, particularly young minority children. This paper describes the design, intervention, recruitment methods, and baseline data of the ongoing Positive Lifestyles for Active Youngsters (Team PLAY) study. This randomized controlled trial is de...

journal_title：Contemporary clinical trials

authors： Hare ME,Coday M,Williams NA,Richey PA,Tylavsky FA,Bush AJ

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Functional dyspepsia (FD) is a common problem affecting up to 10-25% of individuals. FD accounts for significant health care costs and affects quality of life but has no definitive treatment. OBJECTIVES:The Functional Dyspepsia Treatment Trial (FDTT) aims to test whether treatment with an antidepressant (am...

journal_title：Contemporary clinical trials

authors： Talley NJ,Locke GR 3rd,Herrick LM,Silvernail VM,Prather CM,Lacy BE,DiBaise JK,Howden CW,Brenner DM,Bouras EP,El-Serag HB,Abraham BP,Moayyedi P,Zinsmeister AR

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVES:Community Health Workers (CHWs) have been recommended to reduce diabetes disparities, but few robust trials of this approach have been conducted. Limitations of prior studies include: unspecified a priori outcomes; lack of blinded outcome assessments; high participant attrition rates; and lack of attention t...

journal_title：Contemporary clinical trials

authors： Rothschild SK,Martin MA,Swider SM,Lynas CT,Avery EF,Janssen I,Powell LH

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:In 2007, we commenced the Healthy Beginnings Trial (HBT) Phase 1 study, which is the first randomised controlled trial (RCT) to test the effectiveness of an early childhood obesity intervention in children aged up to 2 years. The results were promising with significant improvements in infant feeding practice...

journal_title：Contemporary clinical trials

authors： Wen LM,Baur LA,Rissel C,Flood V,Simpson JM,Hayes A,Hardy LL,Wardle K

更新日期：2012-03-01 00:00:00

abstract：:We report here on the use of interactive telephone technology for collecting longitudinal data in a large randomized non-blinded parallel trial. Data were primarily collected via an automated interactive telephone system which enabled data to be downloaded by researchers periodically via a secure website. Alternative ...

journal_title：Contemporary clinical trials

authors： Russell C,Howel D,Ward-Platt MP,Ball HL

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Evaluation of new therapies for cancer has suffered a paradigm shift in the last years. The use of innovative and more efficient designs is a priority for the scientific community; nevertheless, the use of this kind of design is not yet wide spread. PURPOSE:In this paper will examine the effectiveness of ad...

journal_title：Contemporary clinical trials

authors： López MF,Dupuy JF,Gonzalez CV

更新日期：2012-01-01 00:00:00